Spyre Therapeutics, Inc. SEC filings

Filings

Every filing, newest first. MAJOR and NOTABLE filings lead the app's feed; ROUTINE ones are kept here.

1. NOTABLESCHEDULE 13D/ASpyre Therapeutics, Inc.SYREOct 9

   Spyre Therapeutics, Inc. (SYRE) reports 9.19% stake

   • 9,354,200 shares beneficially owned by Fairmount Funds Management LLC
   • 9.19% of total shares outstanding as of Oct 7, 2026
   • Lock-up agreement entered for 60 days post-Oct 7, 2026 offering

   Fairmount Funds Management LLC, filed by

2. ROUTINE424B5Spyre Therapeutics, Inc.SYREOct 8

   Spyre Therapeutics offers 4,117,648 shares at $85

   • 4,117,648 shares of common stock offered
   • Public offering price of $85 per share
   • Underwriters can buy additional 617,647 shares
3. ROUTINE8-KSpyre Therapeutics, Inc.SYREOct 8

   Spyre Therapeutics raises $350M

   • Entered underwriting agreement with Jefferies, TD Securities, Leerink, and Stifel
   • Offering 4,117,648 shares at $85 each
   • Gross proceeds expected to be $350M
4. ROUTINE424B5Spyre Therapeutics, Inc.SYREOct 5

   Spyre Therapeutics offers common stock

   • Offering shares of common stock
   • Public offering price not specified
   • Underwriters can buy additional shares within 30 days
5. ROUTINE4Spyre Therapeutics, Inc.SYREOct 2

   3 insider filings

   Scott L Burrows, insider filing for SYRE

   Show all 3

   • 4Insider filing for SYREOct 2
   • 4Insider filing for SYREOct 2
   • 4Insider filing for SYREOct 2

   Scott L Burrows

6. ROUTINE144Spyre Therapeutics, Inc.SYREOct 1

   2 Form 144 notices

   Heidy King-Jones, planned sale of SYRE shares

   Show all 2

   • 144Planned insider sale of SYRE sharesOct 1
   • 144Planned insider sale of SYRE sharesOct 1

   Heidy King-Jones

7. ROUTINESCHEDULE 13GSpyre Therapeutics, Inc.SYREOct 1

   Ownership stake disclosure

   Paradigm Biocapital Advisors LP

8. ROUTINE144Spyre Therapeutics, Inc.SYRESep 30

   Scott L Burrows, planned sale of SYRE shares

   Scott L Burrows, reporting

9. ROUTINE8-KSpyre Therapeutics, Inc.SYRESep 8

   Current report

10. ROUTINE4Spyre Therapeutics, Inc.SYRESep 3

    3 insider filings

    Heidy King-Jones, insider filing for SYRE

    Show all 3

    • 4Insider filing for SYRESep 3
    • 4Insider filing for SYRESep 3
    • 4Insider filing for SYRESep 3

    Heidy King-Jones, reporting

11. ROUTINE144Spyre Therapeutics, Inc.SYRESep 1

    Heidy King-Jones, planned sale of SYRE shares

    Heidy King-Jones, reporting

12. ROUTINE8-KSpyre Therapeutics, Inc.SYREAug 25

    Current report

13. ROUTINESCHEDULE 13G/ASpyre Therapeutics, Inc.SYREAug 14

    Ownership stake disclosure by PERCEPTIVE ADVISORS LLC (amended)

    PERCEPTIVE ADVISORS LLC, filed by

14. ROUTINESCHEDULE 13G/ASpyre Therapeutics, Inc.SYREAug 14

    Ownership stake disclosure by RTW INVESTMENTS, LP (amended)

    RTW INVESTMENTS, LP, filed by

15. ROUTINE4Spyre Therapeutics, Inc.SYREAug 10

    Jeffrey W. Albers, insider filing for SYRE

    Jeffrey W. Albers, reporting

16. ROUTINE144Spyre Therapeutics, Inc.SYREAug 7

    2 Form 144 notices

    Jeffrey W. Albers, planned sale of SYRE shares

    Show all 2

    • 144Planned insider sale of SYRE sharesAug 7
    • 144Planned insider sale of SYRE sharesAug 7

    Jeffrey W. Albers, reporting

17. ROUTINE4Spyre Therapeutics, Inc.SYREAug 5

    2 insider filings

    Scott L Burrows, insider filing for SYRE

    Show all 2

    • 4Insider filing for SYREAug 5
    • 4Insider filing for SYREAug 5

    Scott L Burrows, reporting

18. ROUTINE8-KSpyre Therapeutics, Inc.SYREAug 4

    Current report

19. NOTABLE10-QSpyre Therapeutics, Inc.SYREAug 4

    Quarterly report

20. ROUTINE144Spyre Therapeutics, Inc.SYREAug 3

    Scott L Burrows, planned sale of SYRE shares

    Scott L Burrows, reporting

21. ROUTINE4Spyre Therapeutics, Inc.SYREJul 2

    3 insider filings

    Scott L Burrows, insider filing for SYRE

    Show all 3

    • 4Insider filing for SYREJul 2
    • 4Insider filing for SYREJul 2
    • 4Insider filing for SYREJul 2

    Scott L Burrows, reporting

22. ROUTINE144Spyre Therapeutics, Inc.SYREJul 1

    Cameron Turtle, planned sale of SYRE shares

    Cameron Turtle, reporting

23. ROUTINE4Spyre Therapeutics, Inc.SYREJun 26

    Scott L Burrows, insider filing for SYRE

    Scott L Burrows, reporting

24. ROUTINES-3ASRSpyre Therapeutics, Inc.SYREJun 26

    Securities offering

25. ROUTINE144Spyre Therapeutics, Inc.SYREJun 25

    Scott L Burrows, planned sale of SYRE shares

    Scott L Burrows, reporting

26. ROUTINE144Spyre Therapeutics, Inc.SYREJun 23

    Fairmount Funds Management LLC, planned sale of SYRE shares

    Fairmount Funds Management LLC, reporting

27. ROUTINE4Spyre Therapeutics, Inc.SYREJun 23

    2 insider filings

    Peter Evan Harwin, insider filing for SYRE

    Show all 2

    • 4Insider filing for SYREJun 23
    • 4Insider filing for SYREJun 23

    Peter Evan Harwin, reporting · Fairmount Healthcare Fund II L.P., reporting · +2 more

28. NOTABLESCHEDULE 13D/ASpyre Therapeutics, Inc.SYREJun 23

    Ownership stake disclosure by Fairmount Funds Management LLC (amended)

    Fairmount Funds Management LLC, filed by

29. ROUTINE144Spyre Therapeutics, Inc.SYREJun 22

    Michael Thomas Henderson, planned sale of SYRE shares

    Michael Thomas Henderson, reporting

30. ROUTINE8-KSpyre Therapeutics, Inc.SYREJun 15

    Current report

31. ROUTINE4Spyre Therapeutics, Inc.SYREJun 3

    3 insider filings

    Sheldon Sloan, insider filing for SYRE

    Show all 3

    • 4Insider filing for SYREJun 3
    • 4Insider filing for SYREJun 3
    • 4Insider filing for SYREJun 3

    Sheldon Sloan, reporting

32. ROUTINE144Spyre Therapeutics, Inc.SYREJun 3

    Sheldon Sloan, planned sale of SYRE shares

    Sheldon Sloan, reporting

33. ROUTINE8-KSpyre Therapeutics, Inc.SYREJun 1

    Current report

34. ROUTINE4Spyre Therapeutics, Inc.SYREMay 29

    5 insider filings

    Fairmount Healthcare Fund II L.P., insider filing for SYRE

    Show all 5

    • 4Insider filing for SYREMay 29
    • 4Insider filing for SYREMay 29
    • 4Insider filing for SYREMay 29
    • 4Insider filing for SYREMay 29
    • 4Insider filing for SYREMay 29

    Fairmount Healthcare Fund II L.P., reporting · Fairmount Funds Management LLC, reporting · +1 more

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