Illumina reports Q3 2026 results

On October 29, 2026, Illumina, Inc. (the "Company") issued a press release announcing financial results for the third quarter ended September 27, 2026.¹ The full text of the Company's press release is attached hereto as Exhibit 99.1.²

The information furnished pursuant to this Item 2.02 (including Exhibit 99.1) shall not be deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act of 1934³ (the "Exchange Act") or otherwise subject to the liabilities under that Section and shall not be deemed to be incorporated by reference into any filing of the Company under the Securities Act of 1933 or the Exchange Act.

(d) Exhibits.

99.1 Press release dated October 29, 2026, announcing Illumina, Inc.'s financial results for the third quarter ended September 27, 2026⁴

104 Cover Page Interactive Data File (embedded within the Inline XBRL document)⁴

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

ILLUMINA, INC.

Date: October 29, 2026 By: /s/ ANKUR DHINGRA⁵

Name: Ankur Dhingra⁵

Title: Chief Financial Officer⁵

Exhibit Index

Exhibit Number Description

99.1

Press release dated October 29, 2026 announcing Illumina, Inc.'s financial results for the third quarter ended September 27, 2026

104 Cover Page Interactive Data File (embedded within the Inline XBRL document)

Investors:

Conor McNamara

+1.858.291.6421

ir@illumina.com

Media:

Christine Douglass

pr@illumina.com

Illumina Reports Financial Results for Third Quarter of Fiscal Year 2026

San Diego, October 29, 2026 /PRNewswire/ -- Illumina, Inc. (Nasdaq: ILMN) ("Illumina" or the "company") today announced its financial results for the third quarter of fiscal year 2026.

Third quarter 2026 results

• Reported revenue was $1.13 billion for Q3 2026, up 4.2% from Q3 2025.⁶ Revenue excluding tariff refunds was $1.17 billion, up 4.7% after also excluding the impacts of currency, acquisitions, and the Greater China region ("ROW 1 organic revenue growth").

• GAAP operating margin was 27.0% and non ‑ GAAP operating margin, excluding tariff refunds, was 25.0%.⁷

• GAAP diluted EPS was $1.43 and non ‑ GAAP diluted EPS, excluding tariff refunds, was $1.44.⁷

"In the third quarter, healthy clinical demand and robust NovaSeq X placements drove results above our guidance. Based on continued momentum, we are raising our full year revenue and earnings guidance," said Jacob Thaysen, Chief Executive Officer of Illumina. "As we continue to execute our strategy, our innovation is broadening the value of the Illumina ecosystem. Together with our customers, we are laying the foundation for AI to transform our understanding of human biology and improve patient outcomes."

Fiscal year 2026 guidance

For fiscal year 2026 and excluding tariff refunds, Illumina now expects:¹¹

• Total revenue of $4.64-$4.66 billion versus prior guidance of $4.60-$4.64 billion.¹¹

• Organic revenue growth greater than 4% and ROW organic revenue growth greater than 5%, both unchanged versus prior guidance.

• Non-GAAP operating margin of 23.6% versus prior guidance of 23.4%-23.6%.

• Non-GAAP diluted EPS of $5.40-$5.45 versus prior guidance of $5.30-$5.40.¹²

Third quarter results

GAAP Non-GAAP (a) Non-GAAP Excluding Tariff Refunds (b)

(a) See tables in "Results of Operations - Non-GAAP" section below for GAAP and non-GAAP reconciliations.

(b) Excludes the impacts of International Emergency Economic Powers Act (IEEPA) tariff refunds expected to be recovered, consisting primarily of a $79 million benefit recognized as a reduction to cost of revenue in Q3 2026 and a reduction to revenue of $37 million for the portion of tariff refunds that we expect to credit to customers.

1 R OW = rest-of-world, excluding Greater China region due to our inclusion on China's Unreliable Entities List

Capital expenditures for free cash flow purposes were $41 million for Q3 2026. Cash flow provided by operations was $419 million, compared to $284 million in the prior year period.⁸ Free cash flow (cash flow provided by operations less capital expenditures) was $378 million for the quarter, compared to $253 million in the prior year period.⁹ Depreciation and amortization expense was $71 million for Q3 2026. At the close of the quarter, the company held $1.34 billion in cash, cash equivalents and short-term investments.¹⁰

Conference call information

The conference call will begin at 1:30 pm Pacific Time (4:30 pm Eastern Time) on Thursday, October 29, 2026 . Interested parties may access the live webcast via the Investor Info section of Illumina's website or directly through the following link - https://illumina-earnings-call-q3-2026.open-exchange.net/ . To ensure timely connection, please join at least ten minutes before the scheduled start of the call. A replay of the conference call will be posted on Illumina's website after the event and will be available for at least 30 days following.

Statement regarding use of non-GAAP financial measures

The company reports non-GAAP results for diluted earnings per share, gross margin, operating margin, and free cash flow, among others, in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP. The company's financial measures under GAAP include substantial charges such as amortization of acquired intangible assets, among others, that are listed in the reconciliations of GAAP and non-GAAP financial measures included in this press release. Management has excluded the effects of these items in non-GAAP measures to assist investors in analyzing and assessing past and future operating performance. Non-GAAP operating margin and diluted earnings per share are key components of the financial metrics utilized by the company's board of directors to measure, in part, management's performance and determine significant elements of management's compensation. The company encourages investors to carefully consider its results under GAAP, as well as its supplemental non-GAAP information and the reconciliation between these presentations, to more fully understand its business. Reconc